ATI Hematology Practice Exam 2025 - Free Hematology Practice Questions and Study Guide

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What does a peripheral blood smear analyze?

The morphology and distribution of blood cells

A peripheral blood smear is a test that involves spreading a drop of blood on a microscope slide and then staining it to visualize the different types of blood cells. The primary purpose of this analysis is to evaluate the morphology and distribution of blood cells, including red blood cells, white blood cells, and platelets.

When examining a peripheral blood smear, healthcare professionals can assess the size, shape, and overall appearance of these cells, which can provide critical information about a patient’s health. Abnormalities in cell morphology, such as variations in size (anisocytosis), shape (poikilocytosis), or the presence of immature cells, can indicate various conditions, including anemia, infections, or hematological disorders.

The other options, while they address various aspects of hematology, do not encompass the comprehensive purpose of a peripheral blood smear. For instance, evaluating the size and shape of plasma cells is more specific to conditions like multiple myeloma rather than providing a broad analysis of blood cells. The presence of abnormal antibodies is typically assessed through serological tests rather than a peripheral blood smear. Lastly, while white blood cell activity can be inferred from a blood smear, the focus is primarily on their morphology rather than their activity level. Thus, the analysis of

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The size and shape of plasma cells

The presence of abnormal antibodies

The activity level of white blood cells

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